It is the year 2062 and humanity is at the brink of extinction. Tiberium, the mysterious, alien crystalline structure that has infested Earth for decades and served as the primary reason for years of relentless conflict between the Global Defense Initiative (GDI) and the Brotherhood of Nod, is close to rendering the planet uninhabitable. Mankind is on the verge of extinction when Kane, Nod's prophetic leader, emerges from seclusion to deliver GDI the message that he has developed a system that could control Tiberium and harness its power. But he cannot build this "Tiberium Control Network" without GDI's cooperation. Thus, the two opposing factions – GDI and Nod – inevitably find themselves in desperation for the same cause: to stop Tiberium from extinguishing mankind.