The story of Venetica takes place in a sixteenth century styled world where Death is a physical being. Death follows the instructions of a group known as Corpus. Every generation, Corpus must select the successor for Death. In the game's story, the council has accidentally chosen a necromancer who intends to bring complete death and destruction upon the world. This necromancer has immortalized himself through death. The current Death and Corpus cannot stop him. The only person capable of stopping him is Scarlett, who is the daughter of Death. She must cultivate and grow her powers to save her father and the world from the necromancer.