In terms of overall gaming performance, the AMD Opteron 6366 HE is massively better than the Intel Core i7-880 Quad 3.06GHz when it comes to running the latest games. This also means it will be less likely to bottleneck more powerful GPUs, allowing them to achieve more of their gaming performance potential.

The Opteron 6366 HE was released over a year more recently than the Core i7-880 Quad, and so the Opteron 6366 HE is likely to have better levels of support, and will be more optimized for running the latest games.

Both CPUs exhibit very powerful performance, so it probably isn't worth upgrading from one to the other, as both are capable of running even the most demanding games at the highest settings (assuming they are accompanied by equivalently powerful GPUs).

The Opteron 6366 HE has 12 more cores than the Core i7-880 Quad. 16 cores is probably excessive if you mean to just run the latest games, as games are not yet able to harness this many cores. The cores in the Core i7-880 Quad is more than enough for gaming purposes. However, if you intend on running a server with the Opteron 6366 HE, it would seem to be a decent choice.

More important for gaming than the number of cores and threads is the clock rate. Problematically, unless the two CPUs are from the same family, this can only serve as a general guide and nothing like an exact comparison, because the clock cycles per instruction (CPI) will vary so much.

The Opteron 6366 HE and Core i7-880 Quad are not from the same family of CPUs, so their clock speeds are by no means directly comparable. Bear in mind, then, that while the Core i7-880 Quad has a 1.26 GHz faster frequency, this is not always an indicator that it will be superior in performance, despite frequency being crucial when trying to avoid GPU bottlenecking. In this case, however, the difference is probably a good indicator that the Opteron 6366 HE is superior.

Aside from the clock rate, the next-most important CPU features for PC game performance are L2 and L3 cache size. Faster than RAM, the more cache available, the more data that can be stored for lightning-fast retrieval. L1 Cache is not usually an issue anymore for gaming, with most high-end CPUs eking out about the same L1 performance, and L2 is more important than L3 - but L3 is still important if you want to reach the highest levels of performance. Bear in mind that although it is better to have a larger cache, the larger it is, the higher the latency, so a balance has to be struck.

The Core i7-880 Quad has a 24 KB bigger L2 cache than the Opteron 6366 HE, but on the other hand, it is the Opteron 6366 HE that has a 16376 MB bigger L3 cache than the Core i7-880 Quad. In this case, the L2 size is probably what counts, so the Core i7-880 Quad is likely superior in this area.

The maximum Thermal Design Power is the power in Watts that the CPU will consume in the worst case scenario. The lithography is the semiconductor manufacturing technology being used to create the CPU - the smaller this is, the more transistors that can be fit into the CPU, and the closer the connections. For both the lithography and the TDP, it is the lower the better, because a lower number means a lower amount of power is necessary to run the CPU, and consequently a lower amount of heat is produced.

The Opteron 6366 HE has a 10 Watt lower Maximum TDP than the Core i7-880 Quad, and was created with a 13 nm smaller manufacturing technology. What this means is the Opteron 6366 HE will consume slightly less power and consequently produce less heat, enabling more prolonged computational tasks with fewer adverse effects. This will lower your yearly electricity bill slightly, as well as prevent you from having to invest in extra cooling mechanisms (unless you overclock).