Gray Matter will be the first new full-size adventure game by the famous adventure author Jane Jensen since the release of Gabriel Knight 3. Staying true to the Jensen-style, the story interweaves gruesome incidents and supernatural events. Neurobiologist Dr. David Styles is one of the main characters in the game. Ever since losing his wife in a terrible car accident many years ago, he has become a recluse, leaving his English mansion Dread Hill House only on rare occasions. Vagabond and street artist Samantha Everett shows up on his doorstep unexpectedly, at a time when Styles just happens to be looking for a new assistant. Originally from America, she has been travelling Europe for the last few years, and is in desperate need of a job and place of refuge. Her first assignment involves finding six volunteers for an experiment planned by Dr. Styles at Oxford University. The experiment begins harmlessly enough, but soon strange things start happening. Styles is visited by his beloved, but deceased wife. Now it is up to Sam to solve the mysteries of Dread Hill House.