Taking place over a 12 day period, Pathologic is set in a small but mysterious town hit by a deadly and highly infectious disease whose origins are unknown. To fight the epidemic the local authorities send in a doctor, an inquisitor to assess the situation, and then a military commander with orders to destroy the town as a last resort. Along with the authorities’ agents, two volunteer healers find their way to the town-with-no-name along with the doctor, each of them with their own ideas on how this sinister disease came to be.