The game is set in a new city called New Marais, a New Orleans-inspired city, to which protagonist Cole MacGrath heads in order to enhance his electrical abilities further. The game begins with Cole battling the Beast in Empire City, barely escaping alive. Cole, along with his friend Zeke, flees to New Marais to prepare for his inevitable confrontation with the Beast; this is the location where the Ray Sphere was first created. Cole encounters the Militia, a shadowy organization led by a man named Bertrand, and the Corrupted, horribly mutated beings affected by the Ray Sphere. The Militia has taken over New Marais in an attempt to keep all superpowered or abnormal entities away. Cole encounters Wolfe, one of the men involved in the Ray Sphere's creation. Cole will combat the Corrupted and Militia, explore New Marais, and learn about himself, Kessler, and The First Sons along the way while gaining new abilities to face the Beast.