The Binding of Isaac packshot image
Isaac is a roguelike shooter based on the dungeon structure of Zelda (nes). At its core it controls like Smash TV / Robotron in a randomly generated semi RPG world filled with powerups items and special abilities. There is not a traditional leveling system in Isaac, instead we used an item system. Every level will have a treasure room, shop, boss and other secret/special rooms that might contain unique items. Special items come in 4 sets, Usable items, Special Weapon upgrades, Passive upgrades and stat boosters. 90% of items in the game stack, so as you progress your character will change into a monstrous powerhouse not only in stats and abilities but also in appearance.
The Binding of Isaac GPU Performance Comparison Graph

The Binding of Isaac GPU Analysis
Comparing The Binding of Isaac PC system requirements to all GPUs shows that The Binding of Isaac is going to need a graphics card that is capable of DX 9 or OpenGL 2.1.

To get the best visual graphical experience on The Binding of Isaac, aim to have a GPU that has at least 256 MB GPU RAM.

Most bottom end graphics cards currently available today, will probably allow you to play The Binding of Isaac

We are advised that 13 year old graphics cards should be able to run The Binding of Isaac , but there could be a few exceptions to this rule.

Note that most games do not officially support laptop graphics cards, but nowadays many laptop graphics solutions are capable of running modern games. Whether desktop graphics cards or laptop, try searching for your graphics card to compare against the The Binding of Isaac graphics card requirements chart below.