Total Annihilation is set in the far future in the midst of a galactic war, with battles taking place on the surface of planets and moons. The efforts of the player are centered around constructing a defensive base and an offensive force, and conquering opponents. The player is also concerned with gathering resources, reconnaissance and stealth, and evaluation of units and terrain. Battles take place against AI in a story-driven campaign, with the option of playing against other players in a skirmish mode.