Slay the Spire GPU Analysis
Comparing Slay the Spire PC system requirements to all GPUs shows that Slay the Spire is going to need a graphics card that is capable of OpenGL 2.0.

To get the best visual graphical experience on Slay the Spire, aim to have a GPU that has at least 256MB GPU RAM.

Most bottom end graphics cards currently available today, will probably allow you to play Slay the Spire

We are advised that 15 year old graphics cards should be able to run Slay the Spire, but there could be a few exceptions to this rule.

Note that most games do not officially support laptop graphics cards, but nowadays many laptop graphics solutions are capable of running modern games. Whether desktop graphics cards or laptop, try searching for your graphics card to compare against the Slay the Spire graphics card requirements chart below.