In terms of overall gaming performance, the graphical capabilities of the AMD Radeon R9 M395X 4GB are noticeably better than the Nvidia GeForce GTX 780M.

The GeForce GTX 780M has a 48 MHz higher core clock speed and the same number of Texture Mapping Units as the R9 M395X. This results in the GeForce GTX 780M providing 6.2 GTexel/s better texturing performance. This still holds weight but shader performance is generally more relevant, particularly since both of these GPUs support at least DirectX 10.

The GeForce GTX 780M has a 48 MHz higher core clock speed than the R9 M395X and the same number of Render Output Units. This results in the GeForce GTX 780M providing 1.6 GPixel/s better pixeling performance. However, both GPUs support DirectX 9 or above, and pixeling performance is only really relevant when comparing older cards.

The R9 M395X was released over a year more recently than the GeForce GTX 780M, and so the R9 M395X is likely to have better driver support, meaning it will be more optimized for running the latest games when compared to the GeForce GTX 780M.

Both GPUs exhibit very powerful performance, so it probably isn't worth upgrading from one to the other, as both are capable of running even the most demanding games at the highest settings.

The Radeon R9 M395X 4GB and the GeForce GTX 780M have the same amount of video memory, but are likely to provide slightly different experiences when displaying game textures at high resolutions.

The memory bandwidth of the Radeon R9 M395X 4GB and the GeForce GTX 780M are the same, which means the R9 M395X and the GeForce GTX 780M have equal limitations when it comes to graphical data transfer.

The Radeon R9 M395X 4GB has 2048 Shader Processing Units and the GeForce GTX 780M has 1536. However, the actual shader performance of the R9 M395X is 1259 and the actual shader performance of the GeForce GTX 780M is 1224. The R9 M395X having 35 better shader performance and an altogether better performance when taking into account other relevant data means that the R9 M395X delivers a marginally smoother and more efficient experience when processing graphical data than the GeForce GTX 780M.

The Radeon R9 M395X 4GB requires 125 Watts to run and the GeForce GTX 780M requires 122 Watts. The R9 M395X requires 3 Watts more than the GeForce GTX 780M to run. The difference is not significant enough for the R9 M395X to have a noticeably larger impact on your yearly electricity bills than the GeForce GTX 780M.