In terms of overall gaming performance, the graphical capabilities of the AMD Radeon R9 M395X 4GB are noticeably better than the Nvidia GeForce GTX 765M SLI.

The GTX 765M has a 74 MHz higher core clock speed and the same number of Texture Mapping Units as the R9 M395X. This results in the GTX 765M providing 9.5 GTexel/s better texturing performance. This still holds weight but shader performance is generally more relevant, particularly since both of these GPUs support at least DirectX 10.

The GTX 765M has a 74 MHz higher core clock speed than the R9 M395X and the same number of Render Output Units. This results in the GTX 765M providing 2.4 GPixel/s better pixeling performance. However, both GPUs support DirectX 9 or above, and pixeling performance is only really relevant when comparing older cards.

The R9 M395X was released over a year more recently than the GTX 765M, and so the R9 M395X is likely to have better driver support, meaning it will be more optimized for running the latest games when compared to the GTX 765M.

Both GPUs exhibit very powerful performance, so it probably isn't worth upgrading from one to the other, as both are capable of running even the most demanding games at the highest settings.

The Radeon R9 M395X 4GB and the GeForce GTX 765M SLI have the same amount of video memory, but are likely to provide slightly different experiences when displaying game textures at high resolutions.

The R9 M395X has 32 GB/sec greater memory bandwidth than the GTX 765M, which means that the memory performance of the R9 M395X is noticeably better than the GTX 765M.

The Radeon R9 M395X 4GB has 2048 Shader Processing Units and the GeForce GTX 765M SLI has 1536. However, the actual shader performance of the R9 M395X is 1259 and the actual shader performance of the GTX 765M is 1326. The GTX 765M having 67 better shader performance is not particularly notable, as altogether the R9 M395X performs better when taking into account other relevant data.

The Radeon R9 M395X 4GB requires 125 Watts to run and the GeForce GTX 765M SLI requires 125 Watts. The two GPUs require the same amount of wattage to run. As such, there is no need to worry about which will more significantly affect your yearly electricity bills.