In terms of overall gaming performance, the graphical capabilities of the AMD Radeon RX 5300M are noticeably better than the AMD Radeon R9 M395X 4GB.

The Radeon RX 5300M has a 277 MHz higher core clock speed than the R9 M395X, but the R9 M395X has 40 more Texture Mapping Units than the Radeon RX 5300M. As a result, the R9 M395X exhibits a 4.5 GTexel/s better Texture Fill Rate than the Radeon RX 5300M. This still holds weight but shader performance is generally more relevant, particularly since both of these GPUs support at least DirectX 10.

The Radeon RX 5300M has a 277 MHz higher core clock speed than the R9 M395X and the same number of Render Output Units. This results in the Radeon RX 5300M providing 8.9 GPixel/s better pixeling performance. However, both GPUs support DirectX 9 or above, and pixeling performance is only really relevant when comparing older cards.

The Radeon RX 5300M was released over three years more recently than the R9 M395X, and so the Radeon RX 5300M is likely to have far better driver support, meaning it will be much more optimized and ultimately superior to the R9 M395X when running the latest games.

Both GPUs exhibit very powerful performance, so it probably isn't worth upgrading from one to the other, as both are capable of running even the most demanding games at the highest settings.

The R9 M395X has 1024 MB more video memory than the Radeon RX 5300M, so is likely to be much better at displaying game textures at higher resolutions. However, the overall memory performance is about the same.

The Radeon RX 5300M has 64 GB/sec greater memory bandwidth than the R9 M395X, which means that the memory performance of the Radeon RX 5300M is much better than the R9 M395X.

The Radeon RX 5300M has 1408 Shader Processing Units and the Radeon R9 M395X 4GB has 2048. However, the actual shader performance of the Radeon RX 5300M is 1322 and the actual shader performance of the R9 M395X is 1259. The Radeon RX 5300M having 63 better shader performance and an altogether better performance when taking into account other relevant data means that the Radeon RX 5300M delivers a massively smoother and more efficient experience when processing graphical data than the R9 M395X.

The Radeon RX 5300M transistor size technology is 21 nm (nanometers) smaller than the R9 M395X. This means that the Radeon RX 5300M is expected to run slightly cooler and achieve higher clock frequencies than the R9 M395X.

The Radeon RX 5300M requires 85 Watts to run and the Radeon R9 M395X 4GB requires 125 Watts. We would recommend a PSU with at least 450 Watts for the Radeon RX 5300M. The R9 M395X requires 40 Watts more than the Radeon RX 5300M to run. The difference is significant enough that the R9 M395X may have a slight adverse affect on your yearly electricity bills in comparison to the Radeon RX 5300M.