Quadro 4000 is a middle-class professional card based on the 40nm, Fermi architecture.

It's based on the Fermi GF100-100-KD GPU and thus offers 352 Shader Processing Units, 44 TMUs and 40 ROPs, on a 256-bit memory interface of fast GDDR5. The central unit runs at 450MHz and the memory clock operates at up to 702MHz. It has a L2 Cache of 384KB and a rated board TDP of 142 Watts.

Despite exhibiting similarities to GeForce GTX 460, due to being under-clocked and because Quadro 4000's drivers are only certified for professional applications only, its gaming performance is up to 10% slower than GeForce GTS 450.